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Exploring molecular changes
Location: St Michael's and King Henry Building
Biophysics is the study of biological systems using techniques from physics, such as how plant cells transform light into energy.
Equipment in our biophysical laboratories is used to research the structures and functions of molecules. Our laboratories are used by researchers, PhD candidates and some students in their final-year of undergraduate courses.
They use our equipment to study how the structures and functions of molecules change under different conditions such as light, separation and temperature.
They also analyse chemical and bacterial compositions, enzymes, genes and chromosomes to discover what they look like, how they move and how they interact with substrates.
Our biophysical laboratories are located in two buildings across campus: St Michael's Building and King Henry Building.
Explore our lab
Equipment and amenities
St Michael's Building has equipment including:
- Surface Plasmon Resonance (Biacore T200) — used to measure how strongly and quickly two molecules bind by flowing one over a sensor with the other attached, without needing any labels or dyes
- UV-Visible Spectrophotometer (Shimadzu UV-2600) — used to measure how much light a sample absorbs across different wavelengths, helping to work out concentration, purity, and thermal stability by tracking changes in absorbance with temperature
- Fluorescence Spectroscopy (Shimadzu RF-6000) — used to detect fluorescent signals in samples, allowing precise analysis of structure, binding events, and chemical environment
- Plate Reader (Hidex Sense) — used to measure absorbance and fluorescence in up to 96 samples at once, making them ideal for high-throughput assays and screening experiments
- Quantitative PCR (QuantStudio 5) — used to track how much DNA or RNA is in a sample by making copies of it and measuring the amount in real time, ideal for gene expression and genetic analysis
- Circular Dichroism (Chirascan VX) — used to measure how molecules like proteins or DNA twist and fold by analysing how they absorb circularly polarised light, helping to understand their structure, folding, and thermal stability through melt experiments
- Tapestation (Agilent 4150) — used to quickly check the size, quality and concentration of DNA or RNA in a sample by running them through tiny automated gels
- Stopped Flow (SX20) — used to mix two samples in milliseconds and watch what happens right after, helping to capture the fast changes in how molecules react or bind together
Contact us
For research enquiries, please contact biophysics@port.ac.uk
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Where to find us
St Michael's Building
1st floor
St Michael's Building
White Swan Road
Portsmouth
PO1 2DT